036: Molecular classification and subgrouping for personalized treatment of CNS malignancies

HIPO Investigator:

Prof. Pfister

Prof. von Deimling

Prof. Wick

Prof. Heorld-Mende

Dr. Debus

Dr. Witt

Supported by: NCT-POP

Entity: diverse brain tumors


Korshunov A et al.; H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers; Acta Neuropathol 2017

International Cancer Genome Consortium PedBrain Tumor Project; Recurrent MET fusion genes represent a drug target in pediatric glioblastoma; Nature Medicine 2016

Thomas C et al.; Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups; Neuro Oncol 2016

Sahm F et al.; Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets, Acta Neuropathol. 2015

Sturm D et al.; New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs, Cell 2016

Hovestadt et al.; Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays; Acta Neuropathol 2013


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