021: Prospective genetic characterization of tumors from individual patients of special interest

HIPO Investigator:

Prof. Hanno Glimm

Dr. Christof Heining

Dr. Stefan Fröhling

Supported by: NCT-POP and DKFZ-HIPO

Entitiy: various

Publications:

Chudasama P. et al.; Integrative genomic and transcriptomic analysis of leiomyosarcoma; Nat. Commun 2018 (together with H028 and H018)

Czink E et al.; Successful immune checkpoint blockade in a patient with advanced stage microsatellite-unstable biliary tract cancer; Cold Spring Harb Mol Case Stud. 2017

Gröschel S et al.; Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification; Cold Spring Harb Mol Case Stud. 2017

Horak P et al. ; Precision oncology based on omics data: The NCT Heidelberg experience; Int J Cancer 2017

Drennan S et al.; IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus; Leukemia 2017

Chudasama P et al.; Targeting fibroblast growth factor receptor 1 for treatment of soft-tissue sarcoma; Clin Cancer Res 2017

Dieter SM et al.; Mutant KIT as Imatinib-Sensitive Target in Metastatic Sinonasal Carcinoma; Ann Oncol 2017

Czink E et al.; Durable remission under dual HER2 blockade with trastuzumab and pertuzumab in a patient with metastatic gallbladder cancer; Z Gastroenterol 2016

Bochtler T. et al.; Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia; Cold Spring Harb Mol Case Stud 2016

Kordes M et al.; Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling; Leukemia 2016

Yaktapour N et al.; BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia; J Clin Invest 2014

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