HIPO Publications

Literature

2017

Northcott PA et al.; The whole-genome landscape of medulloblastoma subtypes; Nature 2017; DOI: 10.1038/nature22973

 

Sahm F. et al.; DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis; Lancet Oncol. 2017; DOI: 10.1016/S1470-2045(17)30155-9

 

Wegert, J, Vokuhl C, Ziegler C, Ernestus C, Leuschner I, Furtwängler R, Graf N, Gessler M. TP53 alterations in Wilms tumor represent progression events with strong intratumor heterogeneity that are closely linked, but not limited to anaplasia. The Journal of Pathology: Clinical Research 2017

 

Espinet E et al.; Cellular deconvolution and expression analysis of Stromal and Epithelial cells directly isolated from human Pancreatic Ductal Adenocarcinoma (PDAC); Pancreatology 2017

 

Giessler K. et al.; Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer; J Exp Med. 2017; DOI: 10.1084/jem.20162017

 

Bochtler T. et al.; Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia; Blood 2017; DOI: 10.1182/blood-2016-09-738161

 

Ball CR et al.; Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts; EMBO Mol Med 2017; DOI: 10.15252/emmm.201607354

 

Lichter P. and von Kalle C.; Special Section: From Genes to Bedside and Back; Int J Cancer 2017; DOI: 10.1002/ijc.30836

 

Dietz S et al.; Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy; Oncotarget 2017; DOI: 10.18632/oncotarget.18200

 

Horak P et al.; Precision oncology based on omics data: The NCT Heidelberg experience; Int J Cancer 2017; DOI: 10.1002/ijc.30828

 

Sahm F et al.; Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature; Acta Neuropathol 2017; DOI: 10.1007/s00401-017-1715-9

 

Gröschel S et al.; Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification; Cold Spring Harb Mol Case Stud. 2017; DOI: 10.1101/mcs.a001180

 

Winter M et al.; The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A potential mechanism for tobacco smoke–associated atopic dermatitis; J Allergy Clin Immunol.  2017; DOI: 10.1016/j.jaci.2017.01.034

 

Drennan S et al.; IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus; Leukemia 2017; DOI: 10.1038/leu.2016.356

 

Chudasama P et al.; Targeting fibroblast growth factor receptor 1 for treatment of soft-tissue sarcoma; Clin Cancer Res 2017; DOI: 10.1158/1078-0432.CCR-16-0860

 

Dieter SM et al.; Patient‐derived Xenografts of Gastrointestinal Cancers Are Susceptible to Rapid and Delayed B‐Lymphoproliferation; Int J Cancer 2017; DOI: 10.1002/ijc.30561

 

Dieter SM et al.; Mutant KIT as Imatinib-Sensitive Target in Metastatic Sinonasal Carcinoma; Ann Oncol 2017; DOI: 10.1093/annonc/mdw446

 

 

2016

El-Daly SM et al., miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling; Sci. Rep. 2016; DOI: 10.1038/srep24720

 

Fan F et al.; The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment; Leukemia 2016; DOI: 10.1038/leu.2016.358

 

Vita F et al.; Aromatic and proteomic analyses corroborate the distinction between Mediterranean landraces and modern varieties of durum wheat; Sci. Rep. 2016; DOI: 10.1038/srep34619

 

Bartram CR et al.; Position Paper: Cornerstones for an ethically and legally informed practice of whole genome sequencing: code of conduct and patient consent models; Forum Marsilius-Kolleg 2016; DOI: http://dx.doi.org/10.11588/fmk.2015.0.30243

 

International Cancer Genome Consortium PedBrain Tumor Project; Recurrent MET fusion genes represent a drug target in pediatric glioblastoma; Nature Medicine 2016; DOI: 10.1038/nm.4204

 

Kosaloglu, Zeynep, et al. In silico SNP analysis of the breast cancer antigen NY-BR-1; BMC Cancer 2016; DOI: 10.1186/s12885-016-2924-7

 

Johann PD et al.; Cribriform neuroepithelial tumor: Molecular characterization of a SMARCB1‐deficient non‐rhabdoid tumor with favorable long‐term outcome; Brain Pathology 2016; DOI: 10.1111/bpa.12413

 

Thomas C et al.; Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups; Neuro Oncol 2016; DOI: 10.1093/neuonc/nov322

 

Junge KM et al.; Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms; J Allergy Clin Immunol 2016; DOI: 10.1016/j.jaci.2015.06.040

 

Czink E et al.; Durable remission under dual HER2 blockade with trastuzumab and pertuzumab in a patient with metastatic gallbladder cancer; Z Gastroenterol 2016; DOI: 10.1055/s-0042-103498

 

Bochtler T. et al.; Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia; Cold Spring Harb Mol Case Stud 2016; DOI: 10.1101/mcs.a001123

 

Gröschel S et al.; Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification; Cold Spring Harb Mol Case Stud 2016; DOI: 10.1101/mcs.a001180

 

Trump S et al.; Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation; Scientific Reports 2016; DOI: 10.1038/srep28616

 

Gu Z et al.; gtrellis: an R/Bioconductor package for making genome-level Trellis graphics; BMC Bioinformatics 2016; DOI: 10.1186/s12859-016-1051-4

 

Gu Z et al; HilbertCurve: an R/Bioconductor package for high-resolution visualization of genomic data; Bioinformatics 2016; DOI: 10.1093/bioinformatics/btw161

 

Gu Z et al.; Complex heatmaps  reveal  patterns  and  correlations in multidimensional genomic data; Bioinformatics 2016; DOI: 10.1093/bioinformatics/btw313

 

Bauer T et al; Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children, Mol. Syst. Biol. 2016; DOI: 10.15252/msb.20156520

 

Johann PD et al.; Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes, Cancer Cell 2016; DOI: 10.1016/j.ccell.2016.02.001

 

Sturm D et al.; New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs; Cell 2016; DOI: 10.1016/j.cell.2016.01.015

 

Oakes CC et al.; DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia; Nature Genet 2016; DOI: 10.1038/ng.3488

 

Kordes M et al.; Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling; Leukemia 2016; DOI: 10.1038/leu.2015.319

 

Noll EM et al.; CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma; Nat. Med. 2016; DOI: 10.1038/nm.4038

 

 

2015

Abba M et al.;MicroRNAs — from metastasis prediction to metastasis prevention?; Mol Cell Oncol 2015; DOI: 10.1080/23723556.2015.1074336

 

Mudduluru G. et al.; A Systematic Approach to Defining the microRNA Landscape in Metastasis; Cancer Res. 2015; DOI: 10.1158/0008-5472.CAN-15-0997

 

Alioto TS et al.; A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing; Nat Commun 2015; DOI: 10.1038/ncomms10001

 

Sahm F et al.; Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets; Acta Neuropathol. 2015; DOI: 10.1007/s00401-015-1519-8

 

Kretzmer H et al.; DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control; Nat. Genet. 2015; DOI: 10.1038/ng.3413

 

Ruggiero E et al.; High-resolution analysis of the human T-cell receptor repertoire, Nat. Commun. 2015; DOI: 10.1038/ncomms9081

 

Heim S et al.; Papillary tumor of the Pineal Region: A Distinct Molecular Entity, Brain Pathol. 2015; DOI: 10.1111/bpa.12282

 

Korshunov A et al.; Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers; Acta Neuropathol. 2015; DOI: 10.1007/s00401-015-1405-4

 

Gu L et al.; BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence; Nat. Genet. 2015; DOI: 10.1038/ng.3165

 

Pajtler KW et al.; Molecular Classification of Ependymal Tumors across all CNS Compartments, Histopathological Grades, and Age Groups; Cancer Cell 2015; DOI: 10.1016/j.ccell.2015.04.002

 

Haller F et al.; Recurrent Mutations within the amino-Terminal region of β-Catenin Are Probable Key Molecular Driver Events in Sinonasal Hemangiopericytoma; Am J Pathol. 2015; DOI: 10.1016/j.ajpath.2014.10.019

 

Dietrich S et al.; Recurrent CDKN1B (p27) mutations in hairy cell leukemia; Blood 2015; DOI: 10.1182/blood-2015-04-643361

 

Schlesner M and Eils R; Hypermutation takes the driver`s seat; Genome Med. 2015; DOI: 10.1186/s13073-015-0159-x

 

Wegert J et al.; Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors; Cancer Cell 2015; DOI: 10.1016/j.ccell.2015.01.002

 

 

2014

Northcott PA et al.; Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma; Nature 2014; DOI: 10.1038/nature13379

 

Gu Z et al.; circlize Implements and enhances circular visualization in R, Bioinformatics 2014; DOI: 10.1093/bioinformatics/btu393

 

Wiestler B et al.; Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma; Acta Neuropathol. 2014; DOI: 10.1007/s00401-014-1315-x

 

Hutter S et al.; Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants; Acta Neuropathol. 2014; DOI: 10.1007/s00401-014-1311-1

 

Oakes CC et al.; Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia; Cancer Discov. 2014; DOI: 10.1158/2159-8290.CD-13-0349

 

Barthelmeß S et al.; Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features; Am J Pathol. 2014; DOI: 10.1016/j.ajpath.2013.12.016

 

Haller F et al.; Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad;  Endocr. Relat. Cancer 2014; DOI: 10.1530/ERC-14-0254

 

Olins AL et al.; Retrotransposon Alu is enriched in the epichromatin of HL-60 cells; Nucleus 2014; DOI: 10.4161/nucl.29141

 

Hovestadt V et al.; Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing; Nature 2014; DOI: 10.1038/nature13268

 

Wick et al.; A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma; Clin Cancer Res 2014; DOI: 10.1158/1078-0432.CCR-14-0951-T

 

Ball CR et al.; Clonal succession of transiently active tumor-initiating cell clones in human pancreatic cancer drives cancer progression in vivo; Oncol Res Treat 2014; DOI: 10.15252/emmm.201607354

 

Yaktapour et al.; BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia; J Clin Invest 2014; DOI: 10.1172/JCI76539

 

 

2013

Dietrich S et al.; Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia; J Clin Oncol 2013; DOI: 10.1200/JCO.2012.45.9495

 

Jäger N et al.; Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer; Cell 2013; DOI: 10.1016/j.cell.2013.09.042

 

Jethwa A et al.; Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia; BJH 2013; DOI: 10.1111/bjh.12539

 

Jones DT et al.; Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma; Nat. Genet. 2013; DOI: 10.1038/ng.2682

 

 

2012

Jones DT et al.; Dissecting the genomic complexity underlying medulloblastoma; Nature 2012; DOI: 10.1038/nature11284