HIPO Publications



Dietz S et al.; Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy; Oncotarget 2017; DOI: 10.18632/oncotarget.18200


Horak P et al.; Precision oncology based on omics data: The NCT Heidelberg experience; Int J Cancer 2017; DOI: 10.1002/ijc.30828


Sahm F et al.; Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature; Acta Neuropathol 2017; DOI: 10.1007/s00401-017-1715-9


Gröschel S et al.; Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification; Cold Spring Harb Mol Case Stud. 2017; DOI: 10.1101/mcs.a001180


Winter M et al.; The benzene metabolite 1,4-benzoquinone reduces regulatory T-cell function: A potential mechanism for tobacco smoke–associated atopic dermatitis; J Allergy Clin Immunol.  2017; DOI: 10.1016/j.jaci.2017.01.034


Drennan S et al.; IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus; Leukemia 2017; DOI: 10.1038/leu.2016.356


Chudasama P et al.; Targeting fibroblast growth factor receptor 1 for treatment of soft-tissue sarcoma; Clin Cancer Res 2017; DOI: 10.1158/1078-0432.CCR-16-0860


Dieter SM et al.; Patient‐derived Xenografts of Gastrointestinal Cancers Are Susceptible to Rapid and Delayed B‐Lymphoproliferation; Int J Cancer 2017; DOI: 10.1002/ijc.30561


Dieter SM et al.; Mutant KIT as Imatinib-Sensitive Target in Metastatic Sinonasal Carcinoma; Ann Oncol 2017; DOI: 10.1093/annonc/mdw446




El-Daly SM et al., miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling; Sci. Rep. 2016; DOI: 10.1038/srep24720


Fan F et al.; The AP-1 transcription factor JunB is essential for multiple myeloma cell proliferation and drug resistance in the bone marrow microenvironment; Leukemia 2016; DOI: 10.1038/leu.2016.358


Vita F et al.; Aromatic and proteomic analyses corroborate the distinction between Mediterranean landraces and modern varieties of durum wheat; Sci. Rep. 2016; DOI: 10.1038/srep34619


Bartram CR et al.; Position Paper: Cornerstones for an ethically and legally informed practice of whole genome sequencing: code of conduct and patient consent models; Forum Marsilius-Kolleg 2016; DOI: http://dx.doi.org/10.11588/fmk.2015.0.30243


International Cancer Genome Consortium PedBrain Tumor Project; Recurrent MET fusion genes represent a drug target in pediatric glioblastoma; Nature Medicine 2016; DOI: 10.1038/nm.4204


Kosaloglu, Zeynep, et al. In silico SNP analysis of the breast cancer antigen NY-BR-1; BMC Cancer 2016; DOI: 10.1186/s12885-016-2924-7


Johann PD et al.; Cribriform neuroepithelial tumor: Molecular characterization of a SMARCB1‐deficient non‐rhabdoid tumor with favorable long‐term outcome; Brain Pathology 2016; DOI: 10.1111/bpa.12413


Thomas C et al.; Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups; Neuro Oncol 2016; DOI: 10.1093/neuonc/nov322


Junge KM et al.; Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms; J Allergy Clin Immunol 2016; DOI: 10.1016/j.jaci.2015.06.040


Czink E et al.; Durable remission under dual HER2 blockade with trastuzumab and pertuzumab in a patient with metastatic gallbladder cancer; Z Gastroenterol 2016; DOI: 10.1055/s-0042-103498


Bochtler T. et al.; Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia; Cold Spring Harb Mol Case Stud 2016; DOI: 10.1101/mcs.a001123


Gröschel S et al.; Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification; Cold Spring Harb Mol Case Stud 2016; DOI: 10.1101/mcs.a001180


Trump S et al.; Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation; Scientific Reports 2016; DOI: 10.1038/srep28616


Gu Z et al.; gtrellis: an R/Bioconductor package for making genome-level Trellis graphics; BMC Bioinformatics 2016; DOI: 10.1186/s12859-016-1051-4


Gu Z et al; HilbertCurve: an R/Bioconductor package for high-resolution visualization of genomic data; Bioinformatics 2016; DOI: 10.1093/bioinformatics/btw161


Gu Z et al.; Complex heatmaps  reveal  patterns  and  correlations in multidimensional genomic data; Bioinformatics 2016; DOI: 10.1093/bioinformatics/btw313


Bauer T et al; Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children, Mol. Syst. Biol. 2016; DOI: 10.15252/msb.20156520


Johann PD et al.; Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes, Cancer Cell 2016; DOI: 10.1016/j.ccell.2016.02.001


Sturm D et al.; New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs; Cell 2016; DOI: 10.1016/j.cell.2016.01.015


Noll EM et al.; CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma; Nat. Med. 2016; DOI: 10.1038/nm.4038




Sahm F et al.; Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets; Acta Neuropathol. 2015; DOI: 10.1007/s00401-015-1519-8


Kordes M et al.; Cooperation of BRAFF595L and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling; Leukemia 2015; DOI: 10.1038/leu.2015.319


Kretzmer H et al.; DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control; Nat. Genet. 2015; DOI: 10.1038/ng.3413


Ruggiero E et al.; High-resolution analysis of the human T-cell receptor repertoire, Nat. Commun. 2015; DOI: 10.1038/ncomms9081


Junge KM et al.; Increased vitamin D levels at birth and in early infancy increase offspring allergy risk-evidence for involvement of epigenetic mechanisms; J Allergy Clin Immunol. 2015; DOI: 10.1016/j.jaci.2015.06.040


Heim S et al.; Papillary tumor of the Pineal Region: A Distinct Molecular Entity, Brain Pathol. 2015; DOI: 10.1111/bpa.12282


Korshunov A et al.; Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers; Acta Neuropathol. 2015; DOI: 10.1007/s00401-015-1405-4


Gu L et al.; BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence; Nat. Genet. 2015; DOI: 10.1038/ng.3165


Pajtler KW et al.; Molecular Classification of Ependymal Tumors across all CNS Compartments, Histopathological Grades, and Age Groups; Cancer Cell 2015; DOI: 10.1016/j.ccell.2015.04.002


Haller F et al.; Recurrent Mutations within the amino-Terminal region of β-Catenin Are Probable Key Molecular Driver Events in Sinonasal Hemangiopericytoma; Am J Pathol. 2015; DOI: 10.1016/j.ajpath.2014.10.019


Dietrich S et al.; Recurrent CDKN1B (p27) mutations in hairy cell leukemia; Blood 2015; DOI: 10.1182/blood-2015-04-643361


Schlesner M and Eils R; Hypermutation takes the driver`s seat; Genome Med. 2015; DOI: 10.1186/s13073-015-0159-x


Wegert J et al.; Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors; Cancer Cell 2015; DOI: 10.1016/j.ccell.2015.01.002




Northcott PA et al.; Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma; Nature 2014; DOI: 10.1038/nature13379


Gu Z et al.; circlize Implements and enhances circular visualization in R, Bioinformatics 2014; DOI: 10.1093/bioinformatics/btu393


Wiestler B et al.; Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma; Acta Neuropathol. 2014; DOI: 10.1007/s00401-014-1315-x


Hutter S et al.; Whole exome sequencing reveals that the majority of schwannomatosis cases remain unexplained after excluding SMARCB1 and LZTR1 germline variants; Acta Neuropathol. 2014; DOI: 10.1007/s00401-014-1311-1


Oakes CC et al.; Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia; Cancer Discov. 2014; DOI: 10.1158/2159-8290.CD-13-0349


Barthelmeß S et al.; Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features; Am J Pathol. 2014; DOI: 10.1016/j.ajpath.2013.12.016


Haller F et al.; Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad;  Endocr. Relat. Cancer 2014; DOI: 10.1530/ERC-14-0254


Olins AL et al.; Retrotransposon Alu is enriched in the epichromatin of HL-60 cells; Nucleus 2014; DOI: 10.4161/nucl.29141


Hovestadt V et al.; Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing; Nature 2014; DOI: 10.1038/nature13268


Wick et al.; A phase II, randomized, study of weekly APG101+reirradiation versus reirradiation in progressive glioblastoma; Clin Cancer Res 2014; DOI: 10.1158/1078-0432.CCR-14-0951-T


Yaktapour et al.; BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia; J Clin Invest 2014; DOI: 10.1172/JCI76539




Dietrich S et al.; Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia; J Clin Oncol 2013; DOI: 10.1200/JCO.2012.45.9495


Jäger N et al.; Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer; Cell 2013; DOI: 10.1016/j.cell.2013.09.042


Jethwa A et al.; Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia; BJH 2013; DOI: 10.1111/bjh.12539


Jones DT et al.; Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma; Nat. Genet. 2013; DOI: 10.1038/ng.2682




Jones DT et al.; Dissecting the genomic complexity underlying medulloblastoma; Nature 2012; DOI: 10.1038/nature11284